Ongoing research and areas of interest:

Assessment of novel lipoxin in the treatment of murine SLE (with Stan Louie, School of Pharmacy)

Role of B cells and BAFF in generation of T regulatory cells in non-autoimmune and SLE mice

Sex-based and race/ethnicity-based disparities in authorship in high-impact journals and in payments received from industry

Clinical trials:

  • Gilead: Protocol No. GS-US-417-0304: A Multicenter, Double-blind, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects with Rheumatoid Arthritis. IRB: HS-17-00931.

  • Kiniksa: Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Subjects with Moderate to Severe, Active Rheumatoid Arthritis with Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor, In IRB Review process.

  • Norvatis: CVAY736F12301: A randomized, double-blind, parallel group, placebo-controlled multicenter phase 3 study to evaluate efficacy, safety and tolerability of two regimens of ianalumab on top of standard-of-care therapy in patients with systemic lupus erythematosus (SIRIUS-SLE 1) In IRB Review process.

  • XBioTech: Phase II, Double-Blind, Placebo-Controlled, Randomized Trial Examining Natrunix Combination with Methotrexate for the Treatment of Rheumatoid Arthritis. In IRB Review process.

Selected Publications:

  • Peng MG, Zukin LM, Wallace WD, Sibug Saber ME, Arkfeld DG, Chang JR. Arteritic Anterior Ischemic Optic Neuropathy and Central Retinal Artery Occlusion in Polyarteritis Nodosa. J Neuroophthalmol. 2023 Jun 19. doi: 10.1097/WNO.0000000000001911. Epub ahead of print. PMID: 37335682.

  • Wise L, Zell M. Adult-onset Still's disease complicated by macrophage activation syndrome during pregnancy: a case-based review. Clin Rheumatol. 2023 Jun 15. doi: 10.1007/s10067-023-06664-y. Epub ahead of print. PMID: 37322269.

  • Ward NKZ, Pal S, Ruddy K, Savvas S. Attitudes and beliefs towards COVID-19 and COVID-19 vaccination among rheumatology patients in a Los Angeles County safety net clinic. BMC Rheumatol. 2023 Jun 1;7(1):13. doi: 10.1186/s41927-023-00338-7. PMID: 37259135; PMCID: PMC10231953.

  • Alhassan E, Christianakis S. The Mushroom Femoral Head in Legg-Calvé-Perthes Disease. J Clin Rheumatol. 2023 Jun 1;29(4):e57. doi: 10.1097/RHU.0000000000001979. Epub 2023 Apr 26. PMID: 37092897.

  • Alhassan E, Wu KK, Christianakis S, Kim G, Crew A. Clinical Images: Degos-like lesions in association with NXP-2 dermatomyositis. ACR Open Rheumatol. 2023 May 23. doi: 10.1002/acr2.11570. Epub ahead of print. PMID: 37219413.

  • Mehta P, Situ BA, Wise LM, Savvas S, Daskivich LP, Toy BC. Mitigating Hydroxychloroquine Toxicity with a Clinical Decision Support Tool. Ophthalmology. 2023 Aug;130(8):874-876. doi: 10.1016/j.ophtha.2023.04.015. Epub 2023 Apr 25. PMID: 37105380.

  • Lee S, Rodman J, Hsu V, Wise L. Beliefs, Experiences, and Openness Regarding Dietary Interventions: Data From an Urban Hispanic Population With Rheumatic Disease in the US. Arthritis Care Res (Hoboken). 2023 Apr 11. doi: 10.1002/acr.25128. Epub ahead of print. PMID: 37038969.

  • Stohl HE, Stohl W. Maternal and cord blood BAFF and APRIL levels during pregnancy. Am J Reprod Immunol. 2023 Mar;89(3):e13654. doi: 10.1111/aji.13654. Epub 2022 Nov 24. PMID: 36398594.

  • Alhassan E, Christianakis S. Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis. J Clin Rheumatol. 2022 Dec 1;28(8):e707-e708. doi: 10.1097/RHU.0000000000001919. PMID: 36413104.

  • Stohl W, Yu N, Wu Y. B Cell and T Cell Dissimilarities in BAFF-Deficient versus BR3-Deficient C57BL/6 Mice. J Immunol. 2022 Dec 1;209(11):2133-2140. doi: 10.4049/jimmunol.2200620. Epub 2022 Oct 26. PMID: 36426969.

  • Alhassan E, Christianakis S. Diffuse Calcinosis Cutis. J Clin Rheumatol. 2022 Dec 1;28(8):e703. doi: 10.1097/RHU.0000000000001910. Epub 2022 Oct 17. PMID: 36251484.

  • Jiwrajka N, Toothacre NE, Beethem ZT, Sting S, Forsyth KS, Dubin AH, Driscoll A, Stohl W, Anguera MC. Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models. J Autoimmun. 2023 Sep;139:103084. doi: 10.1016/j.jaut.2023.103084. Epub 2023 Jul 1. PMID: 37399593.

  • Izadi Z, Gianfrancesco MA, Schmajuk G, Jacobsohn L, Katz P, Rush S, Ja C, Taylor T, Shidara K, Danila MI, Wysham KD, Strangfeld A, Mateus EF, Hyrich KL, Gossec L, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schaefer M, Al-Emadi S, Sparks JA, Hsu TY, Patel NJ, Wise L, Gilbert E, Duarte-García A, Valenzuela-Almada MO, Ugarte-Gil MF, Ljung L, Scirè CA, Carrara G, Hachulla E, Richez C, Cacoub P, Thomas T, Santos MJ, Bernardes M, Hasseli R, Regierer A, Schulze-Koops H, Müller-Ladner U, Pons-Estel G, Tanten R, Nieto RE, Pisoni CN, Tissera YS, Xavier R, Lopes Marques CD, Pileggi GCS, Robinson PC, Machado PM, Sirotich E, Liew JW, Hausmann JS, Sufka P, Grainger R, Bhana S, Gore-Massy M, Wallace ZS, Yazdany J; COVID-19 Global Rheumatology Alliance Registry. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study. Lancet Rheumatol. 2022 Sep;4(9):e603-e613. doi: 10.1016/S2665-9913(22)00192-8. Epub 2022 Jul 25. PMID: 35909441; PMCID: PMC9313519.

  • Zagelbaum Ward NK, Jun JA, Vecerek N, Donaldson M, Quismorio FP Jr. Dissecting cellulitis of the scalp associated with peripheral and axial spondyloarthritis: report of a case and review of the literature. Clin Rheumatol. 2022 Aug;41(8):2553-2560. doi: 10.1007/s10067-022-06128-9. Epub 2022 Apr 23. PMID: 35460009.

  • Ugarte-Gil MF, Alarcón GS, Izadi Z, Duarte-García A, Reátegui-Sokolova C, Clarke AE, Wise L, Pons-Estel GJ, Santos MJ, Bernatsky S, Ribeiro SLE, Al Emadi S, Sparks JA, Hsu TY, Patel NJ, Gilbert EL, Valenzuela-Almada MO, Jönsen A, Landolfi G, Fredi M, Goulenok T, Devaux M, Mariette X, Queyrel V, Romão VC, Sequeira G, Hasseli R, Hoyer B, Voll RE, Specker C, Baez R, Castro-Coello V, Maldonado Ficco H, Reis Neto ET, Ferreira GAA, Monticielo OAA, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Costello W, Wallace ZS, Jacobsohn L, Taylor T, Ja C, Strangfeld A, Mateus EF, Hyrich KL, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schäfer M, Machado PM, Robinson PC, Gianfrancesco M, Yazdany J. Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 Global Rheumatology Alliance. Ann Rheum Dis. 2022 Jul;81(7):970-978. doi: 10.1136/annrheumdis-2021-221636. Epub 2022 Feb 16. PMID: 35172961; PMCID: PMC8882632.